Brian F. Clem, PhD


Assistant Professor of Medicine; Associate Scientist, James Graham Brown Cancer Center

Research Program
Molecular Targets

Education
B.S., Centre College, 2000
M.S., University of Louisville, 2003
Ph.D., University of Louisville, 2005
Postdoctoral Fellow, University of Louisville James Graham Brown Cancer Center, 2005-2009

Research and Professional Experience
2009-present
Assistant Professor, Department of Medicine, University of Louisville

2009-present
Associate Scientist, James Graham Brown Cancer Center, University of Louisville

Selected Awards and Professional Honors
2002-2003
Center for Genetics and Molecular Medicine Fellowship, University of Louisville

2004-2005
NIEHS T32 ES011564 Training Grant Fellowship

2006-2009
Department of Defense BCRP X81XWH-06-0506 Multi-disciplilnary Postdoctoral Award

Publications

Clem BF, Hudson EA, Clark BJ.  Cyclic adenosine 3',5'-monophosphate (cAMP) enhances cAMP responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter.  Endocrinology 146(3):1348-56, 2005

Clem BF, Clark BJ.  Association of the mSin3A-HDAC1/2 co-repressor complex with the mouse steroidogenic acute regulatory (StAR) protein gene.  Mol Endocrinology 20:100-13, 2006

Clem BF, Telang S, Clem A, Yalcin A, Meier J, Simmons A, Rasku M, Arumugam S, Dean WL, Eaton JW, Lane AN, Trent JO, Chesney J.  Small molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.  Mol Cancer Therapeutics 7(1):110-20, 2008

Liu Y, El-Naggar S, Clem B, Chesney J, Dean DC.  The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression.  Biochem J 412(2):299-306, 2008

Thornburg J, Nelson K, Clem BF, Lane A, Arumugam S, Simmons A, Eaton JW, Telang S, Chesney J. Targeting aspartate aminotransferase in breast cancer.  Breast Cancer Res 10(5):R84, 2008

Liu Y, Clem BF, Zuba-Surma E, El-Naggar S, Telang S, Jenson AB, Ratajczak M, Chesney J, Dean DC. Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell.  Cell Stem Cell 4(4):336-47, 2009

Yalcin A, Telang S, Clem B, Chesney J. Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer. Exp Molec Pathol 86(3):174-9, 2009

Yalcin A, Clem BF, Simmons A, Lane A, Nelson K, Clem AL, Brock E, Siow D, Wattenburg B, Telang S, Chesney J.  Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases. J Biol Chem 284(36):24223-32, 2009

Yalcin A, Clem B, Makoni S, Clem A, Nelson K, Thornburg J, Siow D, Lane AN, Brock SE, Goswami U, Eaton JW, Telang S, Chesney J.  Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling,  Oncogene

Contact Information

CTR Building
505 South Hancock Street
Louisville, KY 40202
(502) 852-8427

Fax: (502) 852-3661