Manicka V. Vadhanam, PhD


Research Program
Prevention & Control

Education
Education/Training

B.Sc., University of Madras, Madras, India, 1985-1988

M.Sc., University of Pondicherry, India, 1988-1991

Ph.D., University of Madras, Madras, India, 1992-1998

Research and Professional Experience

1992-1995      
Junior Research Fellow C,
Cancer Institute, Madras, India

1996-1998      
Senior Research Fellow,
Cancer Institute, Madras, India

1999               
Postdoctoral Fellow,
Leiden University Medical Center, The Netherlands

1999-2002      
Postdoctoral Scholar,
University of Kentucky, Lexington, Kentucky

2002-2003      
Scientist II,
University of Kentucky, Lexington

2003-2005      
Senior Research Associate, James Graham Brown Cancer Center,
University of Louisville, Louisville, Kentucky

2005-present  
Assistant Professor, James Graham Brown Cancer Center,
University of Louisville

Selected Awards and Professional Honors


1990-1991
Joint Secretary, Society of Biological Chemists, Pondicherry Chapter, India

1992-1995
Junior Research Fellowship, Tamil Nadu State Council for Science and Technology, Government of Tamil Nadu, India

1996-1998
Senior Research Fellowship, Council for Scientific and Industrial Research, Government of India

1999
Visiting Scientist Fellowship, Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, Leiden, The Netherlands

Research Interest

Publications

Aqil F, Munagala R, Jeyabalan J, Vadhanam MV* (2013) Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Lett., doi: pii: S0304-3835(13)00158-4. 10.1016/j.canlet.2013.02.032. PMID: 23435377. (*-Corresponding author)

Vadhanam MV, Thaiparambil J, Gairola GC and Gupta RC (2012) Oxidative DNA adducts detected in vitro from redox activity of cigarette smoke constituents. Chem Res Toxicol, 25, 2499-2504. PMID: 22994544

Kausar H, Munagala R, Bansal SS, Vadhanam MV, Aqil F and Gupta RC (2012) Cucurbitacin B potently suppress non-small-cell lung cancer growth: Identification of intracellular thiols as critical targets. Cancer Lett, 332, 35-45. PMID: 23340170.

Aqil F, Munagala R, Kausar H, Jeyabalan J, Vadhanam MV, Gupta RC (2012) Anti-proliferative and antioxidant activity of punicalagins and its protection against oxidative DNA adducts. Food Res Int, 49, 345-353. PMID: 23493479.

Gupta RC, Bansal SS, Aqil F, Jeyabalan J, Cao P, Kausar H, Russell GK, Munagala R, Ravoori S and Vadhanam MV* (2012) Controlled-release systemic delivery – a new concept in cancer chemoprevention. Carcinogenesis, 33, 1608-1615. PMID: 22696595 (*-Co-corresponding author)

Ravoori S, Vadhanam MV, Aqil F and Gupta RC (2012) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry. J Agric Food Chem, 60, 5547-5555. PMID:    22571764.

Aqil F, Jeyabalan J, Kausar H, Bansal SS, Sharma RJ, Singh IP, Vadhanam MV, Gupta RC (2012) Multi-layer polymeric implants for sustained release of chemopreventives. Cancer Lett, 326, 33-40. PMID: 22820161

Aqil F, Vadhanam MV and Gupta RC (2012) Enhanced activity of punicalagin delivered via polymeric implants against benzo[a]pyrene-induced DNA adducts. Mutat Res, 743(1-2), 59-66. PMID: 22234049

Spencer WA, Vadhanam MV, Jeyabalan J and Gupta RC (2012) Oxidative DNA Damage Following Microsome/Cu(II)-Mediated Activation of the Estrogens, 17β-Estradiol, Equilenin, and Equilin: Role of Reactive Oxygen Species. Chem Res Toxicol, 25, 305-314. PMID: 22126130

Vadhanam MV*, Ravoori S, Aqil F and Gupta RC (2011) Chemoprevention of mammary carcinogenesis by sustained systemic delivery of ellagic acid. Eur J Cancer Prev, 20, 484-491. PMID: 21768881 (*-Co-corresponding author)

Jeyabalan J, Vadhanam MV, Ravoori S and Gupta RC (2011) Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants. Chem Res Toxicol, 24, 1937-43. PMID: 21942922.

Cao P, Vadhanam MV, Spencer WA, Cai J and Gupta RC (2011) Sustained Systemic Delivery of Green Tea Polyphenols by Polymeric Implants Significantly Diminishes Benzo[a]pyrene-Induced DNA Adducts. Chem Res Toxicol, 24, 877-886. PMID: 21574630.

Bansal SS, Vadhanam MV and Gupta RC (2011) Development and in vitro-in vivo evaluation of polymeric implants for continuous systemic delivery of curcumin. Pharm Res, 28, 1121-30. PMID: 21311958.

Meireles SI, Esteves GH, Hirata Jr. R, Peri S, Devarajan K, Slifker M, Mosier SL, Vadhanam MV, Hurst HE, Neves EJ, Reis LF, Gairola CG, Gupta RC and Clapper ML (2010) Early Changes in Gene Expression Induced by Tobacco Smoke: Evidence for the Importance of Estrogen within Lung Tissue. Cancer Prev Res, 3, 707-17. PMID: 20515954.

Aiyer HS, Vadhanam MV, Stoyanova R, Caprio GD, Clapper ML and Gupta RC (2008) Dietary Berries and Ellagic Acid Prevent Oxidative DNA Damage and Modulate Expression of DNA Repair Genes. Int. J. Mol. Sci., 9, 327-341. PMID: 19325752.

Ravoori Sξ, Vadhanam MVξ*, Sahoo S, Srinivasan C and Gupta RC (2007) Mammary Tumor Induction in ACI Rats Exposed to Low Levels of 17ß-Estradiol. Int J Oncol., 31, 113-120(ξ*-Equal contribution and Corresponding author).PMID: 17549411