Ramesh C. Gupta, PhD


Agnes Brown Duggan Endowed Chair of Oncological Research, James Graham Brown Cancer Center; Professor of Pharmacology & Toxicology; Senior Scientist, James Graham Brown Cancer Center

Research Program
Prevention & Control

Education

Education/Training
B.Sc., Meerut University, India, Chem/Phys/Maths, 1967
M.Sc., Meerut University, India, Chem (Physical), 1969
Ph.D., University of Roorkee, India, Mech. of Oxidation of Aromatic Aminies, 1972
Post-Doc, Baylor College of Medicine, Houston, TX, Novel Techniques for Sequencing tRNAs, 1973-1976


Research and Professional Experience
1973-1976
Research Associate

1977-1978
Instructor

1978-1989
Assistant Professor and Associate Professor, Baylor College of Medicine

1989-2003
Professor, Preventive Medicine & Environmental Health, Professor in Graduate Center for Toxicology

1998-Present
Faculty Member, Nutritional Science Program, University of Kentucky, Lexington, KY

2003
Professor and Agnes Brown Duggan Chair of Oncological Research, Department of Pharmacology & Toxicology and the Brown Cancer Center, University of Louisville Medical School, Louisville

2003
Member and Head of the Biomarkers, Genetics & Chemoprevention Group, Prevention & Control Program, James Graham Brown Cancer Center, University of Louisville

June 2004
Director of Genetic Susceptibility & Biomarkers Research Core,
University of Louisville

Selected Awards and Professional Honors

Honors in Chemistry and Math, Valedictorian (Gold Medalist) in Master's Program

Merit Scholarship Recipient in B.Sc., M.Sc. and Ph.D. programs

In top 1-2% in High School and College

1981-1982
Our PNAS and Carcinogenesis papers selected for the 1983 and 1984 Year Book of Cancer

1988
PNAS paper selected for the 1990 Year Book of Occupational Medicine

1990
Featured in Cancer Research for co-developing the 32P-Postlabeling DNA Adduct Assay

1990-92
Guest Professor at the Institute of Toxicology, ETH and University of Zurich, Switzerland International Agency for Research on Cancer (IARC), Lyon, France

1996-98
Institute of Toxicology, University of Wuerzburg Medical School, Wuerzburg, Germany

2002-2003
Recipient of Charles W. Wethington, Jr. Award for Research Accomplishments

2003-present
Distinguished University Scholar

2003-present
Agnes Brown Duggan Chair in Oncological Research

Publications

Kausar H, Munagala R, Bansal S, Aqil F Vadhanam MV & Gupta RC. Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets. Cancer Letters, 332(1): 35-45, 2013.
 
Moktar A, Ravoori S, Vadhanam MV, Pan J, Rai SN, Jenson AB, Parker LP & Gupta RC. The interplay of cigarette smoking and HPV infection in human vaginal cells: an ex vivo study. Experimental & Molecular Pathology, 93(3), 422-427, 2012.
 
Vadhanam MV, Thaiparambil J, Gairola CG & Gupta RC. Oxidative DNA adducts detected in vitro from redox activity of cigarette smoke constituents, Chem. Res. Tox., 25: 2499-2504, 2012.
 
Aqil F, Munagala R, Kausar H, Jeyabalan J, Vadhanam MV & Gupta RC. Anti-proliferative and antioxidant activity of punicalagins and its protection against oxidative DNA adducts. Food Research Internatl. 49: 345-353, 2012.
 
Aqil F, Jeyabalan J, Kausar H, Bansal H, Vadhanam MV & Gupta RC. Multi-layer polymeric implants for controlled release of chemopreventives. Cancer Letters, 326: 33-40, 2012.
 
Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh, IP & Gupta RC. Berry anthocyanidins synergistically suppresses growth and metastatic potential of human non-small-cell lung cancer cells. Cancer Letters. 325: 54-62, 2012.
 
Ravoori S, Vadhanam MV, Aqil F & Gupta RC. Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry. Journal of Agricultural and Food Chemistry. 60: 5547-5555, 2012.
 
Gupta RC, Bansal S, Aqil F, Jeyabalan J, Cao P, Kausar H, Russell GK, Munagala R, Ravoori S & Vadhanam MV. Controlled-release systemic delivery - a new concept in cancer chemoprevention. Carcinogenesis. 33:1608–1615, 2012.
 
Aqil F, Gupta A, Munagala R, Jeyabalan, J, Kausar H, Sharma, R, Singh IP & Gupta RC. Antioxidant and antiproliferative potential of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (‘jamun’, the Indian Blackberry). Nutrition & Cancer. 64: 428-438, 2012.
 
Aqil F, Vadhanam MV & Gupta RC. Enhanced activity of punicalagin delivered via polymeric implants against benzo[a]pyrene-induced DNA adducts. Mutation Research. 743: 59-66, 2012.
 
Jeyabalan J, Vadhanam MV, Ravoori S & Gupta RC. Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants. Chem. Res. Tox. 24: 1937-1943, 2011.
 
Munagala R, Kausar H & Gupta RC. Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and up-regulation of tumor suppressor proteins in human cervical cancer cells. Carcinogenesis 322011. :1697-1705.
 
Vadhanam MV, Ravoori S, Aqil F & Gupta RC. Chemoprevention of mammary carcinogenesis by sustained systemic delivery of ellagic acid. Eur J. Cancer Prev. 20:484-491, 2011.
 
Bansal SS, Goel M, Aqil F, Vadhanam M & Gupta RC. Advanced drug-delivery systems of curcumin for cancer chemoprevention. Cancer Prev Res. 4: 1158-1171, 2011.
 
Bansal SS, Vadhanam MV & Gupta RC. Development and in vitro-in vivo evaluation of polymeric implants for continuous systemic delivery of curcumin. Pharm Research, 28:1121-30, 2011.
 
Meireles S, Esteves G, Hirata, Jr. R, Peri S, Devarajan K, Slifker M, Mosier S, Peng J, Vadhanam M, Hurst H, Neves EJ, Reis L, Gairola CG, Gupta RC & Clapper M. Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue. Cancer Prevention Research, 3 (6): 707-717, 2010.

Contact Information

Baxter II Biomedical Research Building
580 South Preston Street
Louisville, KY 40202
(502) 852-3682


Fax: (502) 852-3661