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Vice Chair for Research
Research Interests
EducationBA, Earlham College, Richmond, IN, Biology, 1968
MD, University of Tennessee, Memphis, TN, 1972
Residency, University of Pittsburgh, Pittsburgh, PA, Internal Medicine, 1972-1975
Fellowship, University of Minnesota, Minneapolis, MN, Gastroenterology, 1975-1977
Research and Professional Experience
1977-1982
Staff Physician
Minneapolis VA Medical Center, Minneapolis, Minnesota
1977-1978
Instructor-Medicine
University of Minnesota, Minneapolis VA Medical Center, Minnesota
1978-1982
Assistant Professor
Department of Medicine, University of Minnesota, Minneapolis
1982-1982
Associate Professor
Department of Medicine, University of Minnesota, Minneapolis
1982-1986
Associate Professor
Department of Medicine, Director of Gastroenterology, University of Kentucky College of Medicine, Lexington, Kentucky
1982-2000
Staff Physician
Lexington VA Medical Center, Cooper Drive Division, Lexington
1982-1996
Director of Gastroenterology
Lexington VA Medical Center, Cooper Drive Division, Lexington
1984-present
Adjunct Professor
Instituts of Agrnomique et Veterinaire, Rabat, Morocco
1986-2000
Professor of Medicine
University of Kentucky College of Medicine, Lexington, KY
1986-2000
Director of Gastroenterology
University of Kentucky College of Medicine, Lexington
1989-present
Professor
Department of Clinical Nutrition, School of Allied Health, University of Kentucky
1991-present
Associate
Sanders-Brown Center on Aging, University of Kentucky
1992-2000
Director
General Clinical Research Center (GCRC), University of Kentucky
1994-2000
Vice Chairman for Research
Department of Internal Medicine, University of Kentucky
2000-present
Staff Physician (5/8 FTE)
VA Medical Center, Louisville, Kentucky
2000-present
Director, Gastroenterology
VA Medical Center, Louisville
2000-2005
Professor of Medicine
University of Louisville Medical School
2000-2005
Vice Chairman for Research
Department of Internal Medicine, University of Louisville Medical School
2005-2005
Professor of Internal Medicine
Department of Internal Medicine, Ohio State University, Columbus
2005-2005
Director
Division of Digestive Health, Ohio State University, Columbus
2005-2005
Assistant Senior Vice President for Nutritional Sciences
Ohio State University, Columbus
2000-present
Professor
Department of Toxicology and Pharmacology, University of Louisville Medical School
2000-2005
Director
Clinical Research Center, University of Louisville Medical Center
2000-2005
Jewish Hospital Endowed Chair in Hepatology
University of Louisville Medical School
2000-2005
Director, Liver Research Center
University of Louisville Medical School
Selected Awards and Professional Honors
1991-1992
University of Kentucky Research Professor
1995-1996
President, American College of Nutrition
1996
University of Kentucky College of Medicine Faculty Research Award
1996-2000
Andrade Chair on Hepatology, University of Kentucky
2000-present
Jewish Hospital Distinguished Chair in Hepatology - University of Louisville Medical Center
2001-2003
Board of Directors, American Board of Physician Nutrition Specialists
2005-present
NIH Peer Review Advisory Committee (PRAC)
PublicationsHill D, Marsano L, Cohen D, Allen J, Shedlofsky S, McClain CJ: Increased plasma interleukin-6 activity in alcoholic hepatitis. J Lab Clin Med 119:547-12, 1992
Hill DB, Marsano LS, McClain CJ. Increased Plasma Interleukin-8 Concentrations in Alcoholic Hepatitis. Hepatology 18:576-80, 1993
McClain CJ, Hill DB, Schmidt J, Diehl AM: Cytokines and alcoholic liver disease. Sem Liver Dis 13:170-182, 1993
Shedlofsky SI, Israel B, McClain C, Hill D, Blouin RA. Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. J Clin Invest 94:2209-14, 1994
Gaetke L, McClain CJ, Talwalkar R, Shedlofsky S. Zinc metabolism in human volunteers given endotoxin as a model of gram-negative sepsis. Am J Physiol 272:E952-6, 1997
Eastin CE, McClain CJ, Lee EY, Bagby GJ, Chawla RK. Choline deficiency augments and antibody to tumor necrosis factor-a attenuates endotoxin-induced hepatic injury. Alc Clin Exp Res 21:1037-47, 1997
Chawla R, Watson W, Eastin C, Lee E, Schmidt J, McClain CJ: S-Adenosylmethionine (adomet) deficiency and tumor necrosis factor (TNF) in lipopolysaccharide (LPS) induced hepatic injury. Am J Physiol 275:G125-9, 1998
McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D: Cytokines in alcoholic liver disease. Sem Liver Dis 19:205-19, 1999
Pena LR, Hill DB, McClain CJ. Treatment with glutathione precursor decreases cytokine activity. JPEN 23:1-6, 1999
Hill DB, Devalaraja R, Joshi-Barve S, Barve S, McClain CJ: Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro. Clinical Biochemistry 32:563-70, 1999
Hill DB, Barve S, Joshi-Barve S, McClain C. Increased monocyte nuclear factor-kB activation and tumor necrosis factor production in alcoholic hepatitis. J Lab Clin Med 135:387-95, 2000
Deaciuc IV, Nikolova-Karakashian M, Fortunato F, Lee EY, Hill DB, McClain CJ. Apoptosis and dysregulated ceramide metabolism in a murine model of alcohol-enhanced lipopolysaccharide hepatotoxicity. Alcoholism: Clin Exp Res 24:1557-65, 2000
Yang F, Oz H, Barve S, deVilliers WJS, McClain CJ, Varilek G. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappaB activation by inhibiting IkB kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 60:528-533, 2001
McClain CJ, Hill DB, Song Z, Deaciuc I, Barve S. Monocyte activation in alcoholic liver disease. Alcohol 27:53-61, 2002
McClain CJ, Hill DB, Song Z, Watson W, Chen T, Barve S. S-Adenosylmethionine, cytokines and alcoholic liver disease. Alcohol 27:185-92, 2002.
Lambert JC, Zhou Z, Wang L, Song Z, McClain CJ, Kang YJ. Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice. J Pharmacol Exp Ther 305(3):880-6, 2003
Song Z, Zhou Z, Chen T, Hill D, Kang J, Barve S, McClain CJ. S-Adenosylmethionine protects against acute alcohol hepatotoxicity. J Nutr Biochem 14 591-7, 2003.
Song Z, Barve S, Chen T, Nelson W, Uriarte S, Hill D, McClain CJ. S-Adenosylmethionine modulates endotoxin stimulated interleukin-10 production in monocytes. Am J Physiol Gastrointest Liver Physiol 284:G949-55, 2003.
Lambert JC, Zhou Z, Wang L, Song Z, McClain CJ, Kang YJ. Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice. Am J Pathol 305:880-6, 2003.
Joshi-Barve, S., Barve, S.S., Butt, W., Klein, J., McClain, C.J. Inhibition of proteasome function leads to NF-kappaB-independent IL-8 expression in human hepatocytes. Hepatology 38:1178-87, 2003.
Arteel G, Marsano L, Mendez C, Bentley F, McClain CJ. Advances in alcoholic liver disease. Best Pract.Res.Clin Gastroenterol 17:625-47, 2003.
Song Z, Zhou Z, Uriarte S, Wang L, Kang YJ, Chen T, Barve S, McClain CJ. S-adenosylhomocysteine sensitizes to TNF-a hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease. Hepatology 40:989-97, 2004.
Zhou Z, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ. Abrogation of NF-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced TNF-alpha production and liver injury. Am J Pathol 164:1547-56, 2004.
Mendez CM, McClain CJ, Marsano LS. Albumin therapy in clinical practice. Nutr Clin Pract 20(3):314-20, 2005. Review.
Louthan MV, Theriot JA, Zimmerman E, Stutts JT, McClain CJ. Decreased prevalence of nonalcoholic fatty liver disease in black obese children. J Pediatr Gastroenterol Nutr 41(4):426-9, 2005.
Dryden GW Jr, Deaciuc I, Arteel G, McClain CJ. Clinical implications of oxidative stress and antioxidant therapy. Curr Gastroenterol Rep 7:308-16, 2005. Review.
Zhou Z, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ. Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Am J Pathol 166(6):1681-90, 2005.
Oz HS, Chen TS, McClain CJ, de Villiers WJ. Antioxidants as novel therapy in a murine model of colitis. J Nutr Biochem 16(5):297-304, 2005.
Oz HS, Chen T, de Villiers WJ, McClain CJ. Metallothionein overexpression does not protect against inflammatory bowel disease in a murine colitis model. Med Sci Monit 11:BR69-73, 2005.
Krueger KJ, McClain CJ, McClave SA, Dryden GW. Nutritional supplements and alternative medicine. Curr Opin Gastroenterol 20(2):130-8., 2004
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