Kenneth R. McLeish, MD

Professor

Research Program

Education

Publications

Lederer, ED, Sohi, S, McLeish KR. PTH stimulates extracellular signal-regulated kinase activity through two independent signal transduction pathways.  Role of ERK in sodium-phosphate co-transport.  J Am Soc Nephrol 11:222-231, 2000.

Klein JB, Rane MJ, Coxon PY, Scherzer JA, Mathiesen JM, Buridi A, Kettritz R, McLeish KR.  GM-CSF delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways.  J Immunol 164:4286-4291, 2000.

Rane MJ, Prossnitz ER, Arthur JM, Ward RA, McLeish KR. Impaired homologous desensitization of formyl peptide receptors expressed in undifferentiated HL-60 cells.  Biochem Pharmacol 60:179-187, 2000.

Coxon PY, Rane MJ, Powell DW, Klein JB, McLeish KR. Differential mitogen-activated protein kinase stimulation by Fcg receptor Iia and Fcg receptor IIIb determines the activation phenotype of human neutrophils. J Immunol 164:6530-6537, 2000.

Arthur JM, Lawrence MS, Payne CR, Rane MJ, McLeish KR. The calcium-sensing receptor stimulates JNK in DCK cells. Biochem Biophys Res Comm 275: 538-541, 2000.

Ward RA, Nakamura M, McLeish KR. Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules. J Biol Chem 275:36713-36719, 2000.

Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR.  p38 kinase-dependent MAPKAPK-2 activation functions as PDK2 for Akt in human neutrophils. J Biol Chem 276:3517-3523, 2001.

Klein JB, Buridi A, Coxon PY, Rane MJ, Manning T, Kettritz R, McLeish KR. Role of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.  Cell Signal 13:335-343, 2001.

Blankenship KA, Williams JJ, Lawrence MS, McLeish KR, Dean WL, Arthur JM.  The calcium-sensing receptor inhibits calcium absorption in MDCK cells by inhibition of PMCA. Am J Physiol 280:F815-F822, 2001.

Kato A, Singh S, McLeish KR, Edwards MJ, Lentsch AB.  Mechanisms of hypothermic protection against ischemic liver injury in mice. Am J Physiol Gastrointest Liver Physiol 282;G608-G616, 2002.

Powell DW, Rane MJ, Chen Q, Singh S, McLeish KR.  Identification of 14-4-4zeta as a protein kinase B/Akt substrate. J Biol Chem 277:21639-21642, 2002.

Thongboonkerd V, McLeish KR, Arthur JM, Klein JB.  Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation. Kidney Int 62:1461-1469, 2002.

Ward RA, Ouseph R, McLeish KR. Effects of high-flux hemodialysis on oxidant stress. Cited in RenalWEB.com, Kidney Int 63:353-359, 2002.

Ward RA, McLeish KR.  Oxidant stress in hemodialysis patients: what are the determining factors? Artif Organs 27:230-236, 2003.

Ward RA, Ouseph R, McLeish KR. Effects of high-flux hemodialysis on oxidant stress.  Kidney Int 63:353-359, 2003.

Coxon PY, Rane MJ, Uriarte S, Powell DW, Singh S, Chen Q, McLeish KR.  MAPK-activated protein kinase-2 participates in p38-dependent- and ERK-dependent functions in human neutrophils. Cell Signal 15:993-1001, 2003.

Chen Q, Powell DW, Rane MJ, Singh S, Butt W, Klein JB, McLeish KR.  Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. J Immunol 170:5302-5308, 2003.

Rane MJ, Pan Y, Singh S, Powell DW, Cummins T, Wu R, Chen Q, McLeish KR, Klein JB.  Heat shock protein 27 controls neutrophil survival by regulating PKB/Akt activation. J Biol Chem 278:27828-27835, 2003.

Powell DW, Rane MJ, Dean WL, Pierce WM, Klein JB, McLeish KR.  Proteomic identification of 14-3-3zeta as a MAPK-activated protein kinase-2 substrate. Mol Cell Biol 23:5376-5387, 2003.

Singh S, Powell DW, Rane MJ, Millard TH, Trent JO, Pierce WM, Klein JB, Machesky LM, McLeish, KR. Identification of the p16-Arc subunit of the Arp2/3 complex as a substrate of MAPK-activated protein kinase-2 by proteomic analysis. J Biol Chem 278:36410-36417, 2003.

Thongboonkerd V, Klein JB, Jevans AW, McLeish KR.  Urinary proteomics and biomarker discovery for glomerular disease. Contr Nephrol 141:292-307, 2004.

Thongboonkerd V, Barati M, McLeish KR, Pierce WM, Epstein PN, Klein, JB.  Proteomics and diabetic nephropathy.  Contr Nephrol 141:142-154, 2004

Barati M, Powell DW, McLeish KR. Application of proteomics to kinase pathways in mesangial cells.  Contr Nephrol 141: 231-244, 2004.

Thongboonkerd V, Barati M, McLeish KR, Benarafa C, Remold-O’Donnell E, Zheng S, Pierce WM, Epstein PN, Klein, JB. Alterations in the renal elastin-elastase system in type I diabetic nephropathy identified by proteomic analysis.  J Am Soc Nephrol 15:650-662, 2004.

Ward RA, McLeish KR.  Methylglgoxal: a stimulus to neutrophil oxygen radical production in chronic renal failure. Nephrol Dial Transpl 19:1702-1707, 2004.

Lominadze G, Rane MJ, Merchant M, Cai J, Ward RA, McLeish KR.  Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils.  J Immunol. 174(11):7257-67, 2005.

Rane MJ, Gozal D, Butt W, Gozal E, Pierce WM Jr, Guo SZ, Wu R, Goldbart AD, Thongboonkerd V, McLeish KR, Klein JB.  gamma-Amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusion.  J Immunol 174(11):7242-9, 2005.

Hirano S, Sun X, DeGuzman CA, Ransom RF, McLeish KR, Smoyer WE, Shelden EA, Welsh MJ, Benndorf R.  p38 MAPK/HSP25 signaling mediates cadmium-induced contraction of mesangial cells and renal glomeruli.  Am J Physiol Renal Physiol 288(6):F1133-43, 2005.

Khundmiri SJ, Dean WL, McLeish KR, Lederer ED.  Parathyroid hormone-mediated regulation of Na+-K+-ATPase requires ERK-dependent translocation of protein kinase Calpha. J Biol Chem 280(10):8705-13, 2005

Powell DW, Pierce WM, McLeish KR.  Defining mitogen-activated protein kinase pathways with mass spectrometry-based approaches.  Mass Spectrom Rev 2004 Dec 23; [Epub ahead of print]

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