Jon B. Klein, MD, PhD

Wang GW, Zhou Z, Klein JB, Kang JY.  Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothion-ein overexpressing cardiomyocytes.  Am J Physiol Heart Circ Physiol 281:H2292-99, 2001

Vondriska TM, Klein JB, Kang JY.  The use of functional proteomics to investigate PKCe-mediated cardiopro-tection:  The signaling module hypothesis.  Am J Physiol Heart Circ Physiol 280:H1434-41, 2001

Molestina RE, Klein JB, Miller RD, Ramirez JA, Pierce W, Summersgill JT.  Proteomic analysis of differentially expressed Chlamydia pneumoniae proteins during persistent infection of HEp-2 cells.  Infect Immun 70: 2976-81, 2002

Song C, Vondriska TM, Wang GW, Klein JB, Cao X, Zhang J, Kang YJ, D’Souza S, Ping P.  Molecular conformation dictates signaling module formation; example of PKCepsilon and Src tyrosine kinase.  Am J Physiol Heart Circ Physiol 282(3):H1166-71, 2002

Castegna A, Aksenov M, Aksnoa M, Thongboonkerd V, Klein JB, Pierce WM, Markesberry WR, Butterfield DA.  Proteomic identification of oxidatively modified proteins in Alzheimer’s disease brain. Part 1: Creatine kinase BB, blutamine synthase and ubiquitin carboxy-terminal hydrolase L-1.  Free Radic Biol Med 33:562-71, 2002

Kettriz R, Choi M, Butt W, Rane M, Rolle S, Luft FC, Klein JB.  Phosphatidylinositol 3-kinase/Akt controls ANCA-Induced respiratory burst in human neutrophils.  J Am Soc Nephrol 13(7):1740-49, 2002

Thongboonkerd V, Luengpaillin J, Cao J, Pierce WM, Cai J, Klein JB, Doyle RJ.  Fluoride exposure attenuates expression of Streptococcus pyogenes virulence factors.  J Biol Chem 277(19):16599-605, 2002

Klein JB, Harding G, Klein E.  A new isoelectric focusing gel for two-dimensional electrophoresis constructed in microporous hollow fiber membranes.  J Proteome Res 1(1):41-45, 2002

Thongboonkerd V, McLeish KR, Arthur JA, Klein JB.  Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation.  Kidney Int 62(4):1461-69, 2002

Castegna A, Aksenov M, Thongboonkerd M, Klein JB, Pierce WM, Booze R, Markesbery WR, Butterfield DA.  Proteomic identification of oxidatively modified proteins in Alzheimer’s disease brain. Part II: dihydropyrimi-dinase-related protein 2, a-enolase and heat shock cognate 71.  J Neurochem 82(6):1542-32, 2002

Gozal E, Gozal D, Pierce WM, Thongboonkerd V, Scherzer JA, Sachleben LR Jr, Gio SZ, Cai J, Klein JB.  Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia.  J Neurochem 83(2):331-45, 2002

Klein JB, Wang GW, Zhou Z, Buridi A, Kang YJ.  Inhibition of tumor necrosis factor-alpha-dependent cardiomyocyte apoptosis by metallothionein.  Cardiovasc Toxicol 2(3):209-18, 2002

Chen Q, Powell DW, Rane MJ, Singh S, Butt W, Klein JB, McLeish KR.  Akt phosphorylates p47 (phox) and mediates respiratory burst activity in human neutrophils.  J Immunol 170(10):5302-8, 2003

Thongboonkerd V, Klein JB, Pierce WM, Jevans AW, Arthur JM.  Sodium loading changes urinary protein excretion: a proteomic analysis.  Am J Physiol Renal Physiol 284(6):F1155-63, 2003

Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Tidor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR.  Proteomic identification of 14-3-3 g as a MAPK-activated protein kinase-2 substrate: Role in dimer formation and ligand binding.  Mol Cell Biol 23(15):5376-87, 2003

Zhang SXL, Gozal D, Sachleben LR Jr, Rane M, Klein JB, Gozal E.  Hypoxia induces an autocrine-paracrine survival pathway via PDGF-B/PDGF-beta receptor/PI3K/Akt signaling in RN46A neuronal cells.  FASEB J 17(12):1709-11, 2003

Singh S, Powell DW, Rane JM, Millard TH, Trent JO, Pierce WM, Klein JB, Machesky LM, McLeish KR.  Identification of the p16-Arc subunit of the Arp2/3 complex as a substrate of MAPK-activiated protein kinase-2 by proteomic analysis.  J Biol Chem 278(38):36410-17, 2003

Rane MJ, Pan Y, Sing S, Powell DW, Wu R, Cummins T, Chen Q, Mcleish KR, Klein JB.  Heat shock protein 27 controls apoptosis by regulating Akt activation.  J Biol Chem 278(30)27828-35, 2003

Castegna A, Thongboonkerd V, Klein JB, Lynn B, Markesbery WR, Butterfield DA.  Proteomic identification of nitrated proteins in Alzheimer’s disease brain.  J Neurochem 85(6):1394-1401, 2003

Thongboonkerd V, Klein JB, Arthur JM.  Proteomic analysis of a large complement of urinary proteins.  Nephron Exp Nephrol 95(2):e69-78, 2003.

Castegna A, Thongboonkerd V, Klein JB, Lynn B, Wang YL, Osaka H, Wada K, Butterfield DA.  Proteomic an-alysis of brain proteins in the gracile asonal dystrophy mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins.  J Neurochem 88:1540-46, 2004

Thongboonkerd V, Barati MT, McLeish KR, Benarafa C, Remold-O’Donnell E, Zheng S, Rovin BH, Peirce WM, Epstein PN, Klein JB.  Alterations in the renal elastin-elastase system in Type 1 dabetic nephropathy identified by proteomic analysis.  J Am Soc Nephrol 15 650-62, 2004

Poon HF, Castegna A, Farr SA, Thongboonkerd V, Lynn BC, Banks WA, Morley JE, Klein JB, Buterfield DA.  Quantitative proteomics analysis of specific protein expression and oxidatie modification in aged senescence-accelerated-prone 8 mice brain.  Neuroscience 126(4):915-26, 2004

Kumar KG, Klein JB.  Analysis of expression and posttranslational modification of proteins during hypoxia.  J Appl Physiol 96(3):1176-86, 2004

Thongboonkerd V, Klein JB, Jevans AW, McLeish KR.  Urinary proteomics and biomarker discovery for glomerular diseases.  Contrib Nephrol 141:292-304, 2004

Shen X, ZhenG S, Thongboonkerd V, Xu M, Pierce WM Jr, Klein JB, Epstein PN.  Cardiac mitochondrial dam-age and biogenesis in a chronic model of type 1 diabetes.  Am J Physiol Endocrin Metab 28:E896-905, 2004

Thongboonkerd V, Barati MT, McLeish KR, Pierce WM, Epstein PN, Klein JB.  Proteomics and diabetic nephropathy.  Contrib Nephrol 141:142-54, 2004

Poon HF, Farr SA Thongboonkerd V, Lynn BC, Banks WA Morley JE, Klein JB, Butterfield DA.  Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with a-lipoic acid: implications for aging and age-related neurodegenerative disorders.  Neurochem Int 46(2):159-68, 2005