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Director, Kentucky Lions Eye Center; Chairman Dep't of Ophthalmology and Visual Sciences
Research ProgramTumor Immunobiology
Research Interests
Henry J. Kaplan, MD, is a retina specialist with an interest in “neovascularization” (i.e., abnormal vascular development). In collaboration with Nalini S. Bora, PhD, and Puran S. Bora, PhD, he has identified an important role for the complement cascade in development of neovasculature. Specifically, the membrane attack complex (MAC) appears to be essential to the development of choroidal neovascularization. Studies are currently underway to inhibit choroidal vascularization with the use of Si RNA.
Dr. Kaplan has also explored the use of a human immunoconjugate, an anti-angiogenic agent for choroidal vascularization, as well as tumor angiogenesis. This work is being done in collaboration with Alan Garen, PhD, at Yale University, as well as Tongalp Tezel, MD, and Puran S. Bora, PhD, at the University of Louisville. Using a human immunoconjugate targeted to tissue factor by factor VII, he has demonstrated the ability to inhibit the development of choroidal neovascularization, as well as induce the regression of established abnormal angiogenesis. Preclinical studies are now being completed in conjunction with a biotechnology company, Iconic, Inc., with the goal of clinical application for cancer and age-related macular degeneration.
EducationB.A., Columbia University, New York, NY, 1964
M.D., Cornell Medical School, New York, NY, Medicine, 1968
Fellow, University of Texas Medical School, Dallas, TX, Immunology, 1974
Resident, University of Iowa Hospitals & Clinics, Iowa City, IA, Opthalmology, 1975-1978
Fellowship, Medical College of Wisconsin, Milwaukee, WI, Retina, 1978-1979
Research and Professional Experience
1974-1975
Assistant Professor, Department of Cell Biology,
University Texas (Southwestern) Medical School, Dallax, TX
1979-1984
Associate Professor
Department of Ophthalmology,
Emory University School of Medicine, Atlanta, GA
1984-1988
Professor & Director of Research, Department of Ophthalmology,
Emory University School of Medicine, Atlanta, GA
1988-1998
Professor & Chairman, Department of Ophthalmology and Visual Sciences,
Washington University School of Medicine, St. Louis, MO
1998-2000
Professor of Ophthalmology and Visual Sciences,
Washington University School of Medicine
2000-present
Evans Professor of Ophthalmology,
University of Louisville School of Medicine;
Chairman, Department of Ophthalmology and Visuals Sciences, University of Louisville School of Medicine; Director, Kentucky Lions Eye Center, Louisville, KY
2000-present
Member, James Graham Brown Cancer Center,
University of Louisville, Louisville, KY
Publications
Del Priore LV, Kaplan HJ, Tezel TH, Hayashi N, Berger AS, Green WR. Retinal pigment epithelial transplantation after subfoveal membranectomy in age-related macular degeneration: clinicopathologic correlation. Am J Ophthalmol 131(4):472-80, 2001
Del Priore LV, Geng L, Tezel TH, Kaplan HJ. Extracellular matrix ligands promote RPE attachment to inner Bruch’s Membrane. Curr Eye Res 25(2):79-89, 2002
Sohn JH, Bora PS, Suk HJ, Molina H, Kaplan HJ, Bora NS. Tolerance is dependent on iC3b binding to antigen presenting cells. Nature Medicine 9(2):206-12, 2003
Berger AS, Tezel TH, Del Priore LV, Kaplan HJ. Photoreceptor transplantation in retinitis pigmentosa: short-term follow-up. Ophthalmol 110(2):383-91, 2003
Del Priore LV, Sheng Y, Johnson E, Jacoby DB, Edge A, Suzuki T, Geng L, Tezel T, Kaplan H. Identification of transplanted retinal pigment epithelium with a novel chromosomal marker. Curr Eye Res 26(2):125-31, 2003
Del Priore LV, Ishida O, Johnson EW, Sheng Y, Jackoby DB, Geng L Tezel TH, Kaplan HJ. Triple immune suppression increases short-term survival of porcine fetal retinal pigment epithelium xenographts. Invest Ophthalmol Vis Sci 44(9):4044-53, 2003
Bora PS, Hu Z, Tezel TH, Sohn JH, Kang SG, Cruz JM, Bora NS. Immunotherapy for choroidal neovasculariza-tion in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc Natl Acad Sci USA 100(5):2679-84, 2003
Del Priore L, Kaplan HJ, Tezel TH. Short-term survival of allogenic porcine retinal pigment epithelial sheets after subretinal transplantation. Invest Ophthalmol Vis Sci 45(3):985-92, 2004
Bora NS, Sohn JH, Kang SG, Cruz JMC,Nishihori H, Suk HJ, Wang Y, Kaplan HJ, Bora PS. Type I collagen is the autoantigen in experimental autoimmune anterior uveitis. J Immunol 172 (11):7086-94, 2004
Shao H, Sun SL, Kaplan HJ, Sun D. Characterization of rat CD8+ uveitogenic T cells specific for interphotoreceptor retinal-binding protein 1177-1191. J Immunol 172(4):2849-54, 2004
Tezel TH, DelPriore L, Kaplan HJ. Re-engineering of aged Bruch’s membrane to enhance retinal pigment epithelium repopulation. Invest Ophthalmol Vis Sci 45(9):3337-48, 2004
Tezel TH, Bora NS, Kaplan HJ. Pathogenesis of age-related macular degeneration. Trends in Molec Med 10(9):417-20, 2004
Shao H, Huang Z, Sun SL, Kaplan HJ, Sun D. Myelin/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the C57BL/6 mouse. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4060-5, 2004.
Shao H, Fu Y, Liao T, Peng Y, Chen L, Kaplan HJ, Sun D. Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells. Invest Ophthalmol Vis Sci 46(2):596-603, 2005.
Bora PS, Sohn JH, Cruz JM, Jha P, Nishihori H, Wang Y, Kaliappan S, Kaplan HJ, Bora NS. Role of comple-ment and complement membrane attack complex in laser-induced choroidal neovascularization. J Immunol 174(1):491-97, 2005.
Contact Info Eye Specialists of Louisville, PSC
301 E. Muhammad Ali Blvd.
Louisville, KY 40202
Phone: Appointments (502) 852-5466
Office (502) 852-3716
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