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Assistant Professor, Department of Surgery; Associate Scientist, James Graham Brown Cancer Center
Research ProgramMolecular Targets
Research Interests
Education
Education/Training
B.S., Wuxi College of LI, Jiagsu, China, Microbiology, 1980
M.S., Hangzhou University, Zejiang, China, Biochemistry, 1982
Ph.D., University of Texas at Austin, Molecular Biology, 1993
Postdoc., Howard Hughes Medical Institute, Gene Therapy, 1995
Research and Professional Experience
1993-1995
Postdoctoral Research Associate, Howard Hughes Medical Institute, Baylor College of Medicine, Houston Texas
1995-1998
Cystic Fibrosis Foundation Postdoctoral Fellow, Dept of Mol & Human Genetics, Baylor College of Medicine, Houston Texas
1998-2002
Research Assistant Professor, Department of Molecular and Human Genetics, Shell Center for Gene Therapy, Baylor College of Medicine, Houston Texas
2002-present
Assistant Professor (tenure track), Brown Cancer Center and Department of Medicine, University of Louisville, Louisville, KY
Selected Awards and Professional Honors
1984
Excellent Staff Award, Jiangxi Academy of Sciences, Jiangxi, China
1987-1988
Visiting Scholarship, National Education Commission of China
1991
Member Honor Society of Phi Kappa Phi
1993
Excellent Ph.D. Dissertation, University of Texas at Austin
1995-1998
Postdoctoral Research Fellowship Grant (F984), North American Cystic Fibrosis Foundation
1998
Member American Society of Gene Therapy
2004
Member American Association for Cancer Research
PublicationsO'Neal WK, Rose E, Zhou H, Langston C, Rice K, Carey D, Beaudet AL. Multiple advantages of alpha-fetoprotein as a marker for in vivo gene transfer. Mol Ther 2:640-648. 2000
O'Neal WK, Zhou H, Morral N, Langston C, Parks RJ, Graham FL, Kochanek S, Beaudet AL. Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector. Mol Med 6:179-95. 2000
Zhou H, Zou L, Ozol K, Pastore L, Shine D, Yang K. Stable transgene expression delivered by helper-dependent adenovirus vector in central nervous system. Molec Ther 2:105-113, 2000
Zhou H, Beaudet A. A new cell line with inducible E2a for production of higher titer and safer adenovirus vectors. Virology 275:348-357, 2000
Zou L, Yuan X, Zhou H, Yang K. Characterization of helper-dependent adenoviral vector-mediated gene transfer to aged rat brain. Human Gene Ther 12:181-191, 2001
Zhou H (Corresponding), Zhao T, Zhang W, Rao XM, Beaudet A. A cre expressing cell line and an E1/E2a double deleted helper virus for preparation of helper-dependent adenovirus vector. Mol Ther 3:613-622, 2001
Zou L, Yotnda P, Zhao T, Yuan X, Long Y, Zhou H, Yang K. Reduced inflammatory reactions to the inoculation of helper-dependent adenoviral vectors in traumatically injured rat brain. J Cereb Blood Flow Metab 20:959-970. 2002
Zhou H (Corresponding), Zhao T, Rao XM, Beaudet A. Production of helper-dependent adenovirus vector relies on helper virus structure and complementing. J Gene Medicine 4:498-509, 2002
Zhou H, Pastore L, Beaudet A. Helper-dependent adenovirus vector. Methods in Enzymology 346:177-198, 2002
Zhao T, Rao X, Li, L, Thompson T, McMasters K, Zhou H (Corresponding). Adenovirus with insertion-mutated E1a selectively propagates in liver cancer cells and destroys tumors in vivo. Cancer Res 63:3073-3078, 2003
Dong YB, Duncan B, Souza V, Zhou HS, McMasters KM. E2F-1 cancer gene therapy. Gene Ther Molec Biol 8:147-155, 2004
Rao X, Tseng MT, Zheng X, Dong Y, Jamshidi-Parsian A, Thompson TC, Brenner MK, McMasters KM, Zhou H (Corresponding author). E1A-induced apoptosis does not prevent replication of adenoviruses with deletion of E1b in majority of infected cancer cells. Cancer Gene Ther 11:585-593, 2004
Jamshidi-Parsian A, Dong Y, Zhou H, McMasters KM. Gene expression profiling of E2F-1-induced apoptosis. Gene 344:67-77, 2005
Contact InfoCTR Building
505 South Hancock Street
Louisville, KY 40202
Phone: (502) 852-5745
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